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IN VITRO STUDIES FURTHER DETAILS

In Vitro Study No: 227

METHODS

Chemical

Conc. (mg/ml)

Volume (ml)

Loading (mg/cm2)

Vehicle

Species

Membrane

Site

Area (cm2)

Cell Type

Receptor Fluid

Temp. (oC)

Temp. Measured

Exposure Time (h)

Study Length (h)

Occluded

Analytical Method

N-Hexyl Nicotinate

0.2

0.034

Water

Human

Isolated Epidermis

Abdomen/Breast

5.72

Static

isotonic PBS and NaCl

Not Given

HPLC

RESULTS

% Recovery	+/-	% In Stratum Corneum	+/-	% in Viable Skin	+/-	% Penetrated	+/-	% Absorbed	+/-	s-s-flux (mcrg/cm2/h)	+/-	kp (cm/h)	n	Lag Time (h)
										3.58		0.0179	5

% Recovery

+/-

% In Stratum Corneum

+/-

% in Viable Skin

+/-

% Penetrated

+/-

% Absorbed

+/-

s-s-flux (mcrg/cm2/h)

+/-

kp (cm/h)

Lag Time (h)

3.58

0.0179

NOTES

The top of the chamber was sealed to prevent evaporation. The Kp was given as log Kp, cm/h.10 to the power of 3 which was 1.25. I have converted it to Kp for the purposes of this database.

REFERENCE

Percutaneous Absorption Of Nicotininc Acid Derivatives In Vitro (1991) J. Pharm. Sci., 80 :54-56