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IN VITRO STUDIES FURTHER DETAILS

In Vitro Study No: 261

METHODS

Chemical

Conc. (mg/ml)

Volume (ml)

Loading (mg/cm2)

Vehicle

Species

Membrane

Site

Area (cm2)

Cell Type

Receptor Fluid

Temp. (oC)

Temp. Measured

Exposure Time (h)

Study Length (h)

Occluded

Analytical Method

Testosterone

0.2

0.01

0.0156

Ethanol

Human

Dermatomed to 0.28mm

Breast

0.64

Flow-through

Eagles MEM & 2% PEG (pH 7.4)

Not Given

Radiolabelled (14C)

RESULTS

% Recovery	+/-	% In Stratum Corneum	+/-	% in Viable Skin	+/-	% Penetrated	+/-	% Absorbed	+/-	s-s-flux (mcrg/cm2/h)	+/-	kp (cm/h)	n	Lag Time (h)
										0.00813	0.00521	3.78E-05	3

% Recovery

+/-

% In Stratum Corneum

+/-

% in Viable Skin

+/-

% Penetrated

+/-

% Absorbed

+/-

s-s-flux (mcrg/cm2/h)

+/-

kp (cm/h)

Lag Time (h)

0.00813

0.00521

3.78E-05

NOTES

All samples came from a single donor, who was a smoker. The results were given as +/- SEM I have changed this to SD for the database.

REFERENCE

Interindividual Variability In The Percutaneous Penetration Of Testosterone Through Human Skin In Vitro (2001) Toxicology, 168 :63