IN VITRO STUDIES FURTHER DETAILS
In Vitro Study No: 263
METHODS
Chemical
Conc. (mg/ml)
Volume (ml)
Loading (mg/cm2)
Vehicle
Species
Membrane
Site
Area (cm2)
Cell Type
Receptor Fluid
Temp. (oC)
Temp. Measured
Exposure Time (h)
Study Length (h)
Occluded
Analytical Method
Testosterone
0.2
0.01
0.0156
Ethanol
Human
Dermatomed to 0.28mm
Breast
0.64
Flow-through
Eagles MEM & 2% PEG (pH 7.4)
32
Not Given
24
24
2
Radiolabelled (14C)
RESULTS
% Recovery
+/-
% In Stratum Corneum
+/-
% in Viable Skin
+/-
% Penetrated
+/-
% Absorbed
+/-
s-s-flux (mcrg/cm2/h)
+/-
kp (cm/h)
n
Lag Time (h)
0.00561
0.001
2.61E-05
3
NOTES
All samples came from a single donor
REFERENCE
Interindividual Variability In The Percutaneous Penetration Of Testosterone Through Human Skin In Vitro (2001) Toxicology, 168 :63
