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In Vitro Study No: 301

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
4-Nitroaniline Not Given0.004AcetoneMonkeyDermatomed to 0.35mmAbdomen1.13StaticSaline Not Given24242Radiolabelled (14C)

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
        62.214.9   6 

NOTES

The results were given as +/- SEM I have changed this to SD for the database.

REFERENCE

Percutaneous Absorption Of Nitroaromatic Compunds: In Vivo And In Vitro Studies In The Human And The Monkey (1985) J. Investig. Dermatol., 84 :180-183