IN VITRO STUDIES FURTHER DETAILS
In Vitro Study No: 304
METHODS
Chemical
Conc. (mg/ml)
Volume (ml)
Loading (mg/cm2)
Vehicle
Species
Membrane
Site
Area (cm2)
Cell Type
Receptor Fluid
Temp. (oC)
Temp. Measured
Exposure Time (h)
Study Length (h)
Occluded
Analytical Method
Dinitrochlorobenzene
Not Given
0.004
Acetone
Human
Dermatomed to 0.35mm
Abdomen
1.13
Static
Saline
Not Given
24
24
2
Radiolabelled (14C)
RESULTS
% Recovery
+/-
% In Stratum Corneum
+/-
% in Viable Skin
+/-
% Penetrated
+/-
% Absorbed
+/-
s-s-flux (mcrg/cm2/h)
+/-
kp (cm/h)
n
Lag Time (h)
32.5
24.6
8
NOTES
The results were given as +/- SEM I have changed this to SD for the database.
REFERENCE
Percutaneous Absorption Of Nitroaromatic Compunds: In Vivo And In Vitro Studies In The Human And The Monkey (1985) J. Investig. Dermatol., 84 :180-183
