IN VITRO STUDIES FURTHER DETAILS
In Vitro Study No: 307
METHODS
Chemical
Conc. (mg/ml)
Volume (ml)
Loading (mg/cm2)
Vehicle
Species
Membrane
Site
Area (cm2)
Cell Type
Receptor Fluid
Temp. (oC)
Temp. Measured
Exposure Time (h)
Study Length (h)
Occluded
Analytical Method
2-Nitro-4-Phenylenediamine
Not Given
0.004
Acetone
Monkey
Dermatomed to 0.35mm
Abdomen
1.13
Static
Saline
Not Given
24
24
2
Radiolabelled (14C)
RESULTS
% Recovery
+/-
% In Stratum Corneum
+/-
% in Viable Skin
+/-
% Penetrated
+/-
% Absorbed
+/-
s-s-flux (mcrg/cm2/h)
+/-
kp (cm/h)
n
Lag Time (h)
6.2
2.4
6
NOTES
The results were given as +/- SEM I have changed this to SD for the database.
REFERENCE
Percutaneous Absorption Of Nitroaromatic Compunds: In Vivo And In Vitro Studies In The Human And The Monkey (1985) J. Investig. Dermatol., 84 :180-183
