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In Vitro Study No: 367

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Propoxur1.280.050.1aq. MethanolPigFull Thickness SkinEar0.64Static RPMI, L-glutamine, gentamycin & 10% foetal calf serum37Incubator24242Radiolabelled (14C)

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
92.32.2 10.737.1 41.3 4.20.60.0970.0453 3 

NOTES

6-well tissue culture plates were used in a humidified incubator

REFERENCE

Species Specific Cutaneous Biotransformation Of The Pesticide Propoxur During Percutaneous Absorption In Vitro (1993) Toxicol. Appl. Pharmacol., 123 :144-150