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In Vitro Study No: 394

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Water10000.15375NoneHumanDermatomed to 0.42mmAbdomen0.4Flow-through0.002% Sodium Azide Solution31Skin661Radiolabelled (3H)

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
            0.001349 

NOTES

Donor Compartments were covered. Results are for the eighth day of hydration of the skin

REFERENCE

Shed Snake Skin And Hairless Mouse Skin As Model Membranes For Human Skin During Permeation Studies (1990) J. Investig. Dermatol., 94 :235-240