IN VITRO STUDIES FURTHER DETAILS
In Vitro Study No: 553
METHODS
Chemical
Conc. (mg/ml)
Volume (ml)
Loading (mg/cm2)
Vehicle
Species
Membrane
Site
Area (cm2)
Cell Type
Receptor Fluid
Temp. (oC)
Temp. Measured
Exposure Time (h)
Study Length (h)
Occluded
Analytical Method
Lindane
120
10.5
1.6
Acetone
Human
Dermatomed to 0.23mm
Breast/Abdomen
0.79
Static
50% aq. Ethanol
32
Skin
6
6
2
Gas Chromatography
RESULTS
% Recovery
+/-
% In Stratum Corneum
+/-
% in Viable Skin
+/-
% Penetrated
+/-
% Absorbed
+/-
s-s-flux (mcrg/cm2/h)
+/-
kp (cm/h)
n
Lag Time (h)
90.71
14.2
0.2
0.24
10.73
14.71
0.27
0.16
0.71
0.29
11
NOTES
The % Absorption was given as +/- SEM. I have converted this to SD for this database. % Penetrated was calculated by adding the amount found in the receptor fluid to the amount found in the skin and stratum corneum.
REFERENCE
The Percutaneous Absorption And Skin Distribution Of Lindane In Man. II. In Vitro Studies (1997) Hum. Exp. Toxicol., 16 :652-657
