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In Vitro Study No: 557

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Lindane510.50.0666.25% Pentachlorophenyl laurate 93% White SpiritHumanDermatomed to 0.23mmBreast/Abdomen0.79Static50% aq. Ethanol32Skin662Gas Chromatography

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
84.6 16.25.45.26.831.7 10.34.251.40.76 5 

NOTES

The vehicle was a commercial product which also contained 0.125% "proprietary ingredients" The % Absorption was given as +/- SEM. I have converted this to SD for this database. % Penetrated was calculated by adding the amount found in the receptor fluid to the amount found in the skin and stratum corneum.

REFERENCE

The Percutaneous Absorption And Skin Distribution Of Lindane In Man. II. In Vitro Studies (1997) Hum. Exp. Toxicol., 16 :652-657