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In Vitro Study No: 571

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Dodecyl decaethoxylate80.020.203MethanolRatDermatomed to 0.28mmDorsal0.79Static50% aq. Ethanol35Receptor Fluid24242Radiolabelled (14C)

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
95.4 4.70.34.20.358.3 49.418.23.438 0.0004296 

NOTES

Results were given as +/- SEM. I have converted this to SD for the purpose of this database

REFERENCE

Prediction Of The Percutaneous Penetration And Metabolism Of Dodecyl Decaethoxylate In Rats Using In Vitro Models (1995) Arch. Toxicol., 69 :649-654