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In Vitro Study No: 572

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Dodecyl decaethoxylate80.020.203MethanolRatDermatomed to 0.28mmDorsal0.79Static50% aq. Ethanol35Receptor Fluid24241Radiolabelled (14C)

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
94.5 4.115.50.572.5 62.915.36.615 0.00086 

NOTES

Occluded with Parafilm. Results were given as +/- SEM. I have converted this to SD for the purpose of this database

REFERENCE

Prediction Of The Percutaneous Penetration And Metabolism Of Dodecyl Decaethoxylate In Rats Using In Vitro Models (1995) Arch. Toxicol., 69 :649-654