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In Vitro Study No: 573

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Dodecyl decaethoxylate10.70.020.25MethanolRatDermatomed to 0.28mmDorsal0.64Flow-throughEagles MEM35 24242Radiolabelled (14C)

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
      21.38 76.051.05  8 

NOTES

Results were given as +/- SEM. I have converted this to SD for the purpose of this database

REFERENCE

Prediction Of The Percutaneous Penetration And Metabolism Of Dodecyl Decaethoxylate In Rats Using In Vitro Models (1995) Arch. Toxicol., 69 :649-654