IN VITRO STUDIES FURTHER DETAILS
In Vitro Study No: 576
METHODS
Chemical
Conc. (mg/ml)
Volume (ml)
Loading (mg/cm2)
Vehicle
Species
Membrane
Site
Area (cm2)
Cell Type
Receptor Fluid
Temp. (oC)
Temp. Measured
Exposure Time (h)
Study Length (h)
Occluded
Analytical Method
Mannitol
1
Not Given
Distilled Water
Rat
Isolated Epidermis
Dorsal
0.64
Flow-through
0.9% physiological saline
32
Water Bath
2
Radiolabelled (14C)
RESULTS
% Recovery
+/-
% In Stratum Corneum
+/-
% in Viable Skin
+/-
% Penetrated
+/-
% Absorbed
+/-
s-s-flux (mcrg/cm2/h)
+/-
kp (cm/h)
n
Lag Time (h)
0.000905
6
NOTES
Albino (Wistar) Male Rats were used.Get more experimental detail from Fundamental and Applied Toxicology (1992) 19 484-492
REFERENCE
Skin Absorption: Flow-Through Or Static Diffusion Cells (1994) Toxicol. Vitro, 8 :827-830
