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IN VITRO STUDIES FURTHER DETAILS


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In Vitro Study No: 579

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Mannitol1Not Given Distilled WaterPigFull Thickness SkinOuter Ear2.54Static0.9% physiological saline Water Bath  2Radiolabelled (14C)

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
            0.00063626 

NOTES

Pig Ears were obtained from the abattoir and were cleaned and shaved before use. Get more experimental detail from Fundamental and Applied Toxicology (1992) 19 484-492

REFERENCE

Skin Absorption: Flow-Through Or Static Diffusion Cells (1994) Toxicol. Vitro, 8 :827-830