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IN VITRO STUDIES FURTHER DETAILS


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In Vitro Study No: 606

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Butoxyethyl Triclopyr See Notes15None (Neat)RatFull Thickness SkinDorsal0.32Flow-throughHEPES buffered HBSS & 0.5% gentamycin32Skin72722Radiolabelled (14C)

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
87.64.5 6.163 66.7 3.70.3   7 

NOTES

Find out density.

REFERENCE

Percutaneous Absorption Of Nicotinic Acid, Phenol, Benzoic Acid And Triclopyr Butoxyethanol Ester Through Rat And Human Skin In Vitro: Further Validation Of An In Vitro Model By Comparison With In Vivo Data (1992) Food Chem.Toxicol., 30 :891-899