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IN VITRO STUDIES FURTHER DETAILS

In Vitro Study No: 607

METHODS

Chemical

Conc. (mg/ml)

Volume (ml)

Loading (mg/cm2)

Vehicle

Species

Membrane

Site

Area (cm2)

Cell Type

Receptor Fluid

Temp. (oC)

Temp. Measured

Exposure Time (h)

Study Length (h)

Occluded

Analytical Method

Butoxyethyl Triclopyr

See Notes

None (Neat)

Human

Full Thickness Skin

Breast

0.32

Flow-through

HEPES buffered HBSS & 0.5% gentamycin

Skin

Radiolabelled (14C)

RESULTS

% Recovery	+/-	% In Stratum Corneum	+/-	% in Viable Skin	+/-	% Penetrated	+/-	% Absorbed	+/-	s-s-flux (mcrg/cm2/h)	+/-	kp (cm/h)	n	Lag Time (h)
95.1	5.8		1.2	5.1		5.1		0.7	0.1				7

% Recovery

+/-

% In Stratum Corneum

+/-

% in Viable Skin

+/-

% Penetrated

+/-

% Absorbed

+/-

s-s-flux (mcrg/cm2/h)

+/-

kp (cm/h)

Lag Time (h)

95.1

5.8

1.2

5.1

0.7

0.1

NOTES

Find out density. Healthy human breast Skin was obtained at surgery.

REFERENCE

Percutaneous Absorption Of Nicotinic Acid, Phenol, Benzoic Acid And Triclopyr Butoxyethanol Ester Through Rat And Human Skin In Vitro: Further Validation Of An In Vitro Model By Comparison With In Vivo Data (1992) Food Chem.Toxicol., 30 :891-899