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IN VITRO STUDIES FURTHER DETAILS


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In Vitro Study No: 63

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Testosterone Not Given0.015EthanolHumanFull Thickness SkinAbdomen0.64Staticculture medium & 10% BSA32Water Bath22222Radiolabelled (14C)

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
        9.7   0.000125 

NOTES

Method described in Toxicology and Applied Pharmocology 123, 144-150. (1993)

REFERENCE

In Vitro Percutaneous Penetration Of Testosterone Through Viable "Full-Thickness" Skin And Epidermal Membranes (2000) Poster, :