IN VITRO STUDIES FURTHER DETAILS
In Vitro Study No: 631
METHODS
Chemical
Conc. (mg/ml)
Volume (ml)
Loading (mg/cm2)
Vehicle
Species
Membrane
Site
Area (cm2)
Cell Type
Receptor Fluid
Temp. (oC)
Temp. Measured
Exposure Time (h)
Study Length (h)
Occluded
Analytical Method
2-Ethoxyethanol
931
0.02
5.93
None (Neat Application)
Human
Full Thickness Skin
Abdomen
3.14
Flow-through
Physiological Solution
37
Water Bath
4
4
2
Gas Chromatography
RESULTS
% Recovery
+/-
% In Stratum Corneum
+/-
% in Viable Skin
+/-
% Penetrated
+/-
% Absorbed
+/-
s-s-flux (mcrg/cm2/h)
+/-
kp (cm/h)
n
Lag Time (h)
820.2
0.000882
1
NOTES
REFERENCE
Skin Absorption Of Solvents: Evaluation In Experimental Conditions (1994) Occup. Hyg., 1 :191-198
