IN VITRO STUDIES FURTHER DETAILS
In Vitro Study No: 632
METHODS
Chemical
Conc. (mg/ml)
Volume (ml)
Loading (mg/cm2)
Vehicle
Species
Membrane
Site
Area (cm2)
Cell Type
Receptor Fluid
Temp. (oC)
Temp. Measured
Exposure Time (h)
Study Length (h)
Occluded
Analytical Method
2-Ethoxyethanol
279.3
0.02
1.78
Acetone
Human
Full Thickness Skin
Abdomen
3.14
Flow-through
physiological solution
37
Water Bath
4
4
2
Gas Chromatography
RESULTS
% Recovery
+/-
% In Stratum Corneum
+/-
% in Viable Skin
+/-
% Penetrated
+/-
% Absorbed
+/-
s-s-flux (mcrg/cm2/h)
+/-
kp (cm/h)
n
Lag Time (h)
7.4
4.6
832.8
0.00298
0.72
NOTES
Cadaver Male Skin was used.
REFERENCE
Skin Absorption Of Solvents: Evaluation In Experimental Conditions (1994) Occup. Hyg., 1 :191-198
