IN VITRO STUDIES FURTHER DETAILS
In Vitro Study No: 633
METHODS
Chemical
Conc. (mg/ml)
Volume (ml)
Loading (mg/cm2)
Vehicle
Species
Membrane
Site
Area (cm2)
Cell Type
Receptor Fluid
Temp. (oC)
Temp. Measured
Exposure Time (h)
Study Length (h)
Occluded
Analytical Method
Dimethylformamide
875
0.2
5.57
None (Neat)
Human
Full Thickness Skin
Abdomen
3.14
Flow-through
physiological solution
37
Water Bath
4
4
2
Gas Chromatography
RESULTS
% Recovery
+/-
% In Stratum Corneum
+/-
% in Viable Skin
+/-
% Penetrated
+/-
% Absorbed
+/-
s-s-flux (mcrg/cm2/h)
+/-
kp (cm/h)
n
Lag Time (h)
8400
0.0096
0.935
NOTES
Cadaver Male Skin was used.
REFERENCE
Skin Absorption Of Solvents: Evaluation In Experimental Conditions (1994) Occup. Hyg., 1 :191-198
