IN VITRO STUDIES FURTHER DETAILS
In Vitro Study No: 64
METHODS
Chemical
Conc. (mg/ml)
Volume (ml)
Loading (mg/cm2)
Vehicle
Species
Membrane
Site
Area (cm2)
Cell Type
Receptor Fluid
Temp. (oC)
Temp. Measured
Exposure Time (h)
Study Length (h)
Occluded
Analytical Method
Testosterone
Not Given
0.015
Ethanol
Rat
Isolated Epidermis
Abdomen
0.64
Static
culture medium & 10% BSA
32
Water Bath
22
22
2
Radiolabelled (14C)
RESULTS
% Recovery
+/-
% In Stratum Corneum
+/-
% in Viable Skin
+/-
% Penetrated
+/-
% Absorbed
+/-
s-s-flux (mcrg/cm2/h)
+/-
kp (cm/h)
n
Lag Time (h)
11.8
0.0002
5
NOTES
The rats were young male albinos. The Method is described in Toxicology and Applied Pharmocology 123, 144-150. (1993)
REFERENCE
In Vitro Percutaneous Penetration Of Testosterone Through Viable "Full-Thickness" Skin And Epidermal Membranes (2000) Poster, :
