EDETOX logo

IN VITRO STUDIES FURTHER DETAILS


BACK TO THE MAIN MENU

back to previous page forward to next page

 University of Newcastle homepage

In Vitro Study No: 66

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Testosterone Not Given0.015EthanolRatIsolated EpidermisAbdomen0.64Staticculture medium & 10% BSA32Water Bath22222Radiolabelled (14C)

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
        58   0.002875 

NOTES

Rats were Sprague-Dawley. Method described in Toxicology and Applied Pharmocology 123, 144-150. (1993)

REFERENCE

In Vitro Percutaneous Penetration Of Testosterone Through Viable "Full-Thickness" Skin And Epidermal Membranes (2000) Poster, :