Wistar Male Albino 11 week old rats were used.The integrity of the skin was tested with [3H]labelled water. The Potential absorbed dose was calculated from the applied dose minus the dose left on the surface at the end of the experiment, this was 28.8mcrg/cm2. The % Absorption after 4 hours was 1.07+/-0.33. The permeability coefficient was calculated by dividing the steady state flux by the concentration applied. |