| 26-day old Male Sprague-Dawley Rats were used. The epidermal membranes were prepared by overnight immersion of the skin in 2M NaBr. The integrity of the skin was tested with [3H]labelled water. The Potential absorbed dose was calculated from the applied dose minus the dose left on the surface at the end of the experiment this was 54mcrg/cm2. The % Absorption after 4 hours was 13.93+/-1.93. The permeability coefficient was calculated by dividing the steady state flux by the concentration applied. |
