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IN VITRO STUDIES FURTHER DETAILS


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In Vitro Study No: 682

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Parathion13300.0000030.004None (Neat)HumanDeramtomed to 0.5mmBack1Flow-throughEagles-MEM-BSS & gentamycin37Water Bath96962Radiolabelled (14C)

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
        1.780.41  0.0001894 

NOTES

Human Cadaver skin was used.

REFERENCE

Predicting Chemical Warfare Agent VX Toxicity To Uniformed Soldier Using Parathion In Vitro Human Skin Exposure And Absorption (2000) Toxicol. Appl. Pharmacol., 168 :149-152