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In Vitro Study No: 689

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Chlordecone Not Given Not GivenRatFull Thickness SkinDorsal0.64StaticModified MEM pH 7.3 Not Given72722Radiolabelled (14C)

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
        2.2130.753   3 

NOTES

Young Female Fischer Rats were used. % Absorption was given +/- SE. I have converted this to SD for the database. Further Experimental Detail is available from: Hall, LL et al (1992) Fundam. Appl. Toxicol. 19 258-267

REFERENCE

Percutaneous Absorption And Disposition Of [14C]Chlordecone In Young And Adult Female Rats (1998) Environ. Res, 79 :138-155