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IN VITRO STUDIES FURTHER DETAILS

In Vitro Study No: 691

METHODS

Chemical

Conc. (mg/ml)

Volume (ml)

Loading (mg/cm2)

Vehicle

Species

Membrane

Site

Area (cm2)

Cell Type

Receptor Fluid

Temp. (oC)

Temp. Measured

Exposure Time (h)

Study Length (h)

Occluded

Analytical Method

Chlordecone

Not Given

Rat

Full Thickness Skin

Dorsal

0.32

Flow-through

Modified MEM pH 7.3

Not Given

Radiolabelled (14C)

RESULTS

% Recovery	+/-	% In Stratum Corneum	+/-	% in Viable Skin	+/-	% Penetrated	+/-	% Absorbed	+/-	s-s-flux (mcrg/cm2/h)	+/-	kp (cm/h)	n	Lag Time (h)
								1.388	0.099				3

% Recovery

+/-

% In Stratum Corneum

+/-

% in Viable Skin

+/-

% Penetrated

+/-

% Absorbed

+/-

s-s-flux (mcrg/cm2/h)

+/-

kp (cm/h)

Lag Time (h)

1.388

0.099

NOTES

Young Female Fischer Rats were used. % Absorption was given +/- SE. I have converted this to SD for the database. Further Experimental Detail is available from: Hall, LL et al (1992) Fundam. Appl. Toxicol. 19 258-267

REFERENCE

Percutaneous Absorption And Disposition Of [14C]Chlordecone In Young And Adult Female Rats (1998) Environ. Res, 79 :138-155