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IN VITRO STUDIES FURTHER DETAILS

In Vitro Study No: 695

METHODS

Chemical

Conc. (mg/ml)

Volume (ml)

Loading (mg/cm2)

Vehicle

Species

Membrane

Site

Area (cm2)

Cell Type

Receptor Fluid

Temp. (oC)

Temp. Measured

Exposure Time (h)

Study Length (h)

Occluded

Analytical Method

Pentachlorophenol

Not Given

0.0008

Acetone

Human

Dermatomed to 0.5mm

Not Given

Flow-through

Human Plasma

Not Given

Radiolabelled (14C)

RESULTS

% Recovery	+/-	% In Stratum Corneum	+/-	% in Viable Skin	+/-	% Penetrated	+/-	% Absorbed	+/-	s-s-flux (mcrg/cm2/h)	+/-	kp (cm/h)	n	Lag Time (h)
93.3	5.7		1.7	3.7		4.3		0.6	0.09				3

% Recovery

+/-

% In Stratum Corneum

+/-

% in Viable Skin

+/-

% Penetrated

+/-

% Absorbed

+/-

s-s-flux (mcrg/cm2/h)

+/-

kp (cm/h)

Lag Time (h)

93.3

5.7

1.7

3.7

4.3

0.6

0.09

NOTES

The 3 replicates came from one human skin source. % Penetrated has been calculated by adding the amount found in the receptor fluid to the amount found in the skin after washing at the end of the experiment.

REFERENCE

Percutaneous Absorption Of Pentachlorophenol From Soil (1993) Fundam. Appl. Toxicol., 20 :68-71