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In Vitro Study No: 702

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Boric Acid515WaterHumanDeramatomed to 0.5mmThigh1Flow-throughPBS32Skin24242Radiolabelled (10B) & !CPMS

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
        0.28 0.58 0.000126 

NOTES

Human Cadaver Skin was used. Teflon cells were used to avoid possible boron contamination from glass.

REFERENCE

In Vivo Percutaneous Absorption Of Boric Acid, Borax, and Disodium Octaborate Tetrahydrate In Humans Compared To In Vitro Absorption In Human Skin From Infinite And Finite Doses (1998) Toxicol. Sci., 45 :42-51