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In Vitro Study No: 703

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Boric Acid0.510.5WaterHumanDeramatomed to 0.5mmThigh1Flow-throughPBS32Skin24242Radiolabelled (10B) & !CPMS

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
        1.2 0.25 0.00056 

NOTES

Human Cadaver Skin was used. Teflon cells were used to avoid possible boron contamination from glass.

REFERENCE

In Vivo Percutaneous Absorption Of Boric Acid, Borax, and Disodium Octaborate Tetrahydrate In Humans Compared To In Vitro Absorption In Human Skin From Infinite And Finite Doses (1998) Toxicol. Sci., 45 :42-51