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IN VITRO STUDIES FURTHER DETAILS


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In Vitro Study No: 803

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Arsenic0.420.0050.0021WaterHumanDermatomed to 0.5mmNot Given1Flow-throughPBS Not Given24242Radiolabelled (73As)

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
71.715.4 0.960.98 1.91 0.931.1   9 

NOTES

 

REFERENCE

In Vivo And In Vitro Percutaneous Absorption And Skin Decontamination Of Arsenic From Water And Soil (1993) Fundam. Appl. Toxicol., 20 :336-340