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In Vitro Study No: 860

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Dinoseb1.9060.0230.0685AcetoneRatDermatomed to 0.35Dorsal0.64StaticMEM, 4% FBS, aspartic acid, serine & gentamycin32Water Bath48482Radiolabelled (14C)

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
        70.9      

NOTES

Young female Fischer rats were used. The % Absorption was given as +/- 8.4 SEM, but they did not mention the number of studies done so I was unable to convert this to SD for the database.

REFERENCE

Age-related Percutaneous Penetration Of 2-Sec-Butyl-4,6-Dinitrophenol (Dinoseb) In Rats (192) Fundam. Appl. Toxicol., 19 :258-267