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In Vitro Study No: 894

METHODS

Chemical Conc. (mg/ml)Volume (ml)Loading (mg/cm2)VehicleSpeciesMembraneSiteArea (cm2)Cell TypeReceptor FluidTemp. (oC)Temp. MeasuredExposure Time (h)Study Length (h)OccludedAnalytical Method
Aroclor 1242 Not Given Mineral OilHumanDermatomed to 0.3mmNot Given Flow-throughSaline Not Given17172Radiolabelled (14C)

RESULTS

% Recovery+/-% In Stratum Corneum+/-% in Viable Skin+/-% Penetrated+/-% Absorbed+/-s-s-flux (mcrg/cm2/h)+/-kp (cm/h)nLag Time (h)
               

NOTES

Percutaneous Absorption was less than 1%. The majority of the radioactivity was recovered in the surface and stratum corneum layers and the epodermis and skin layer though they do not give the results. Similar findings were found for Aroclor 1254 in Mineral oil and trichlorobenzene. Low recovery was achieved for Aroclor 1242 in Trichlorobenzene probably due to loss of the substance by evaporation.

REFERENCE

Percutaneous Absorption And Skin Decontamination Of PCBs: In Vitro Studies With Human Skin And In Vivo Studies In The Rhesus Monkey (1990) J. Toxicol. Environ. Health, 31 :235-246