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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 120

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
2-Methoxyethanol	Infinite	0.004		Air	Human	Forearm and Hand	1000	2	0.75	Gas Chromatography

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
48									128

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

128

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
					5	36

NOTES

The volunteers were 2 men and 3 women. 4000mg/m3 EE was used. The subject sat in a clean air cabin to avoid inhalatory exposure. Their arm was placed in an exposure cylinder (volume 6.5l). Medical air at a flow rate of 31/min from a compressed air cylinder was led through a bottle containing neat EE the vapour stream was led through teflon tubes into and out of the exposure cylinder. Total Dermal Uptake was 128mg +/- 64mg. Constant Absorption rates were assumed.

REFERENCE

Dermal Absorption of Vaprous And Liquid 2-Methoxyethanol and 2-Ethoxyethanol In Volunteers (1997) Int. Arch. Occup. Environ. Health, 54 :38-43