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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 121

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
2-Ethoxyethanol	Infinite	930		None	Human	Volar Forearm	27	1	0.25	Gas Chromatography

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
48									5.2

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

5.2

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
	700	300			5

NOTES

As the dose was infinite, evaporation did not affect the study, so it is recorded as an occluded study. The volunteers were 2 men and 3 women. Pure liquid EE was placed in a glass chamber on the arm. Total Dermal uptake was 5.2mg +/- 2.2mg

REFERENCE

Dermal Absorption of Vaprous And Liquid 2-Methoxyethanol and 2-Ethoxyethanol In Volunteers (1997) Int. Arch. Occup. Environ. Health, 54 :38-43