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IN VIVO STUDIES FURTHER DETAILS


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In Vivo Study No: 122

METHODS

ChemicalMembraneConcentration mg/mlConcentration mg/mlloading (mg/cm2)SpeciesSiteArea (cm2)Occluded?Exposure Time (h)Analytical Method
2-MethoxyethanolInfinite965 NoneHumanVolar Forearm2710.25Gas Chromatography

RESULTS

Length of Study (h)% Recovery+/-Dose remaining on surface (mg)% remaining on SurfaceDose remaining in stratum corneum (mg)% remaining in stratum corneumDose remaining in the viable skin% remaining in the viable skinAmount Absorbed (mg)% Absorbed+/-% Absorbed
48        20   
Maximal Flux (mcrg/cm2/h)Average Flux (mcrg/cm2/h)+/-Time Plasma/Blood Levels Peaked (h)Peak Blood Concentration (mg/l)nkp (cm/h)Lag Time (h)
 29002000  5  

NOTES

As the dose was infinite, evaporation did not affect the study, so it is recorded as an occluded study. The volunteers were 2 men and 3 women. Pure liquid ME was placed in a glass chamber on the arm. Total Dermal uptake was 20mg +/- 11mg

REFERENCE

Dermal Absorption of Vaprous And Liquid 2-Methoxyethanol and 2-Ethoxyethanol In Volunteers (1997) Int. Arch. Occup. Environ. Health, 54 :38-43