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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 126

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
Triclosan	0.1	18.68	0.195	Ethanol/water 9:1	Rat	Back	9.6	2	24	Radiolabelled (3H)

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
24	90.46	4.6	0.5139	27.51	0.679	36.33	0.0807	4.31	0.3822	20.46		20.46

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
					3

NOTES

The rats were all female and weighed ~ 150g. A Silicone O ring was used to hold the dose, covered by a non-occlusive glass cover. % Absorption was calcculated from the sum of the amounts found in the urine (0.88) + faeces (11.84) + blood (0.02) + carcass (7.72). They also studied the metabolism of Triclosan by HPLc but that data is not included in this database.

REFERENCE

Percutaneous Penetration And Dermal Metabolism Of Triclosan (2000) J. Pharmacol. Exp. Ther., 38 :361-370