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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 127

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
Diazinon	0.05	0.4	0.002	Acetone	Human	Ventral Forearm	10	2	24	Radiolabelled (14C)

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
168			0.0001	0.5	2E-06	0.01			0.00077	3.85	2.16	3.85

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

168

0.0001

0.5

2E-06

0.01

0.00077

3.85

2.16

3.85

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
					6

NOTES

% absorption was determined from the urinary 14C excretion corrected for incomplete/other route excretion with monkey urinary disposition after intravenous administration

REFERENCE

Percutaneous Absorption Of Diazinon In Humans (1993) Food Chem.Toxicol., 8 :569-572