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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 129

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
Diazinon	0.05	0.294	0.00147	Lanolin wool grease	Human	Abdomen	10	2	24	Radiolabelled (14C)

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
168			7E-05	0.35	8E-06	0.04			0.000422	2.87	1.16	2.87

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

168

7E-05

0.35

8E-06

0.04

0.000422

2.87

1.16

2.87

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
					6

NOTES

& absorption was determined from the urinary 14C excretion corrected for incomplete/other route excretion with monkey urinary disposition after intravenous administration

REFERENCE

Percutaneous Absorption Of Diazinon In Humans (1993) Food Chem.Toxicol., 8 :569-572