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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 136

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
Malathion	Not Given		0.004	Acetone	Human	Ventral Forearm	13	2	24	Radiolabelled (14C)

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
120									0.041	7.84	2.71	7.84

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

120

0.041

7.84

2.71

7.84

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
					7

NOTES

Corrected for incomplete urinary excretion by comparison with an IV dose administered to a Guinea Pig as it was too toxic to be intravenously administered to man

REFERENCE

Absorption Of Some Organic Compounds Through The Skin In Man (1970) J. Investig. Dermatol., 54 :399-404