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IN VIVO STUDIES FURTHER DETAILS


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In Vivo Study No: 138

METHODS

ChemicalMembraneConcentration mg/mlConcentration mg/mlloading (mg/cm2)SpeciesSiteArea (cm2)Occluded?Exposure Time (h)Analytical Method
Salicylic acidNot Given 0.004AcetoneHumanVentral Forearm13224Radiolabelled (14C)

RESULTS

Length of Study (h)% Recovery+/-Dose remaining on surface (mg)% remaining on SurfaceDose remaining in stratum corneum (mg)% remaining in stratum corneumDose remaining in the viable skin% remaining in the viable skinAmount Absorbed (mg)% Absorbed+/-% Absorbed
120        0.011822.7813.2522.78
Maximal Flux (mcrg/cm2/h)Average Flux (mcrg/cm2/h)+/-Time Plasma/Blood Levels Peaked (h)Peak Blood Concentration (mg/l)nkp (cm/h)Lag Time (h)
     17  

NOTES

Corrected for incomplete urinary excretion by comparison with an IV dose.

REFERENCE

Absorption Of Some Organic Compounds Through The Skin In Man (1970) J. Investig. Dermatol., 54 :399-404