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IN VIVO STUDIES FURTHER DETAILS


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In Vivo Study No: 178

METHODS

ChemicalMembraneConcentration mg/mlConcentration mg/mlloading (mg/cm2)SpeciesSiteArea (cm2)Occluded?Exposure Time (h)Analytical Method
TestosteroneNot Given 0.004AcetoneRatDorsal102120Radiolabelled (14C)

RESULTS

Length of Study (h)% Recovery+/-Dose remaining on surface (mg)% remaining on SurfaceDose remaining in stratum corneum (mg)% remaining in stratum corneumDose remaining in the viable skin% remaining in the viable skinAmount Absorbed (mg)% Absorbed+/-% Absorbed
120        0.0189647.42.6247.4
Maximal Flux (mcrg/cm2/h)Average Flux (mcrg/cm2/h)+/-Time Plasma/Blood Levels Peaked (h)Peak Blood Concentration (mg/l)nkp (cm/h)Lag Time (h)
     4  

NOTES

The % applied dose recovered in the urine was divided by the % dose recovered in the urine after intravenous administration to give the % absorption. Sprague-Dawley rats were used.The hair on the application site was removed the day before with clippers.

REFERENCE

Skin Permeability In Vivo Comparison In Rat, Rabbit, Pig And Man (1972) J. Investig. Dermatol., 58 :114-123