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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 192

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
Cortisone	Not Given		0.004	Acetone	Pig	Dorsal	50	2	120	Radiolabelled (14C)

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
120									0.00812	4.06	1.58	4.06

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

120

0.00812

4.06

1.58

4.06

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
					2

NOTES

The % applied dose recovered in the urine was divided by the % dose recovered in the urine after intravenous administration to give the % absorption. Minature Swine 2-3 months old were used.The hair on the application site was removed the day before with clippers.

REFERENCE

Skin Permeability In Vivo Comparison In Rat, Rabbit, Pig And Man (1972) J. Investig. Dermatol., 58 :114-123