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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 2

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
Chlorpyrifos	0.1	285.9	0.367	Water	Human	Inner Fore Arm	78	1	8	HPLC

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
100	54		15.15	53

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

100

15.15

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
	0.456				5	1.6E-06

NOTES

The application site was occluded with a raised impermeable plastic container. The study was conducted with 4 men and 1 woman. A commercial Preparation of Chlorpyrifos was used. 46% of the dose was left unaccounted for.

REFERENCE

Oral And Dermal Absorption Of Chloropyrifos: A Human Volunteer Study (1999) Occup. Environ. Med., 56 :10-13