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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 206

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
Phoxim	10	250		Macrogel	Pig	Back		2	240	Gas Chromatography

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
240									33.75	1.35		1.35

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

240

33.75

1.35

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
			11.5	0.023	4

NOTES

OP's were extracted from plasma using hexane containing ethion as the internal standard. 2 Pigs were used and 2 experiments on each pig. Dose was given as 100mg/kg and the Pigs weighed an average of 25kg. They gave the % Absorption (Bioavailability) as 1.2-1.5. I have entered the median of this into the database. AUC (microm.g.h/l) was given as 885-1178 Cmax (peak blood concentration ) was given as 16.6-29.4 microg/l Tmax was given as 8-15h Again I have entered the median of this into the database

REFERENCE

Percutaneous Absorption of Organophosphorus Insecticides In Pigs. The Influence Of Different Vehicles (1993) J. Vet. Pharmacol. Therapeut., 16 :174-180