EDETOX logo

IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 210

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
Lindane	1	120	1.6	Acetone	Human	Forearm	75	2	6	Gas Chromatography

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
72			95.16	79.3

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

95.16

79.3

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
				0.00091	4

NOTES

The time to peak plasma levels was between 3 and 45 hours, which is why I haven't included it in the database. After the area had been swabbed at 6h a gauze was placed over the area for protection. AUC was 46,8+/- 2.9 ng/ml/h. 11.2microg of 2,4,6-trichlorophenol were found in the urine after 72h. I have not been able to include this as there were other detectable metabolites of lindane present in the urine and that data was not included.

REFERENCE

The Percutaneous Absorption And Skin Distribution Of Lindane In Man. I. In Vivo Studies (1997) Hum. Exp. Toxicol., 16 :645-651