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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 211

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
Lindane	1	3	0.04	White Spirit Formmulation	Human	Forearm	75	2	6	Gas Chromatography

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
72			0.315	10.5

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

0.315

10.5

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
			6.5	0.00047	4

NOTES

After the area had been swabbed at 6h a gauze and shirt were worn over the area for protection. AUC was 14.1+/- 4.0 ng/ml/h. 4.9microg of 2,4,6-trichlorophenol were found in the urine after 72h. I have not been able to include this as there were other detectable metabolites of lindane present in the urine and that data was not included.

REFERENCE

The Percutaneous Absorption And Skin Distribution Of Lindane In Man. I. In Vivo Studies (1997) Hum. Exp. Toxicol., 16 :645-651