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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 215

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
Nitrobenzene	Not Given		0.004	Acetone	Monkey	Abdomen	13	2	24	Radiolabelled (14C)

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
120									0.218	4.2	1	4.2

Length of Study (h)

% Recovery

+/-

Dose remaining on surface (mg)

% remaining on Surface

Dose remaining in stratum corneum (mg)

% remaining in stratum corneum

Dose remaining in the viable skin

% remaining in the viable skin

Amount Absorbed (mg)

% Absorbed

+/-

% Absorbed

120

0.218

4.2

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
					4

NOTES

Skin was shaved before application. Results were obtained from the amount excreted in the urine corrected for excretion by other routes by determineing the amount excreted in the urine after parental administration in separate experiments. The results were given as +/- SEM I have changed this to SD for the database.

REFERENCE

Percutaneous Absorption Of Nitroaromatic Compunds: In Vivo And In Vitro Studies In The Human And The Monkey (1985) J. Investig. Dermatol., 84 :180-183