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IN VIVO STUDIES FURTHER DETAILS

In Vivo Study No: 239

METHODS

Chemical	Membrane	Concentration mg/ml	Concentration mg/ml	loading (mg/cm2)	Species	Site	Area (cm2)	Occluded?	Exposure Time (h)	Analytical Method
Dodecyl decaethoxylate	0.1	29.57	0.307	Ethanol	Rat	Dorsal	9.62	2	48	Radilabelled (14C)

RESULTS

Length of Study (h)	% Recovery	+/-	Dose remaining on surface (mg)	% remaining on Surface	Dose remaining in stratum corneum (mg)	% remaining in stratum corneum	Dose remaining in the viable skin	% remaining in the viable skin	Amount Absorbed (mg)	% Absorbed	+/-	% Absorbed
48	96.96	1.15	1.51	51.06			0.677	22.91	0.6642	22.49		22.49

Maximal Flux (mcrg/cm2/h)	Average Flux (mcrg/cm2/h)	+/-	Time Plasma/Blood Levels Peaked (h)	Peak Blood Concentration (mg/l)	n	kp (cm/h)	Lag Time (h)
					4

NOTES

Sprague-Dawley Rats were used. Dose left in the skin included the amount left in the stratum corneum. % Absoprtion was calculated from the amount found in the urine, faeces, blood and carcass. The ethanol was allowed to evaporate before the occlusive cover was applied.

REFERENCE

Prediction Of The Percutaneous Penetration And Metabolism Of Dodecyl Decaethoxylate In Rats Using In Vitro Models (1995) Arch. Toxicol., 69 :649-654